The Wikipedia list of Well known Supervillains contains exactly forty nine names. Only one of them is female. Whether this is an error and it was only supposed to be a list of male villains (since there is also a list of supervillainesses) anyway, or because only one female villain has really made an impact on popular culture equivilent to Fu Manchu or The Joker is not clear because that one female name is Servalan.
Servalan is quite simply the archetypal female super villain. She is the embodiment of the empowered woman. She is clever, capricious, sexy, ruthless, and as cuddly as a pit full of vipers armed with laser sights. She dresses to kill. That is to say she dresses extravigantly and people usually die in her immediate vicinity. And she really enjoys her work.
As the arch-villain of the british TV show Blake's Seven she is considerably more successful than the heroes. Despite Blake and Co. having the useful advantages of owning the most powerful and fastest spaceship in the galaxy, the only teleport system in existance (against which there is no defence), and an omniscient computer that can hack any other computer, they stumble around having the occasional inconsequential success in their revolutionary cause, while Servalan works her way up (over any number of dead bodies) to become President of the Federation. After the power of the Federation is broken (due to alien invasion, nothing to do with Blake's bunch) and Servalan is deposed, it is no time at all before she is building her second empire under the name of Commander Slear.
And in the end she wins.
Which is more than most villains can boast.